On-demand Webinar

Rescuing the Unsolvable – A Case Study

Location: Webinar - Virtual
Start Date: Jul 17, 2024
Type of Event: Webinars

This webinar has since taken place and is now available on-demand.

About the Webinar

How to turn a poorly soluble drug into a high performing formulation in just six weeks with scarce API availability?

Our early formulation expert Fabrizio Fina presents the case study of ID11916 and explains how, from its initial water-insoluble state, it was quickly transformed into an innovative oral formulation, accelerating its path to the human clinical trial phase.

The webinar is introduced by Zsolt Lendvai, Research Leader, Pharmaceutical Development Science and Strategy at Evotec, who  also moderates the Q&A session.

Webinar Highlights

  1. Phase-Appropriate Formulation Screening:
    -
    Understand how to tailor formulation screening based on the molecule’s physicochemical properties.
    - Discover key decision points during drug discovery that impact overall development cost and success.
  2. Process Development and Short-Term Stability Assessment:
    Explore techniques for optimizing drug formulation processes.
    - Learn how to assess short-term stability to ensure robust formulations.
  3. In Vitro Biorelevant Performance Testing:
    Dive into biorelevant performance testing methods.
    - Gain insights into predicting in vivo behavior from in vitro data.

The webinar was held on July 17th - The on-demand version is available upon request below. 

Meet Our Speakers

Headshot of Fabrizio Fina
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Fabrizio Fina

Senior Scientist, Early Formulation

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Latest update: May 2024

Biography


Fabrizio joined Evotec in 2020 and is a Senior Scientist within the Early Formulation Group at the Evotec site in Abingdon, UK. He earned his degree in Pharmacy in Italy before pursuing a MSc in Drug Delivery and a PhD in Pharmaceutics at University College London.


His expertise extends to solubilization techniques for both small and large molecules, utilizing minimal compound quantities. He possesses proficiency in a broad spectrum of formulations, ranging from liquids to solids, with a specialization in enhancing solubility and permeability through strategies such as amorphous solid dispersion and lipid-based formulations.

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Headshot of Zsolt Lendvai
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Zsolt Lendvai

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Latest update: May 2024

Biography


Zsolt Lendvai joined Evotec in 2017 and currently holds the position of Research Leader within the Pharmaceutical Development Science and Strategy Group in Verona, Italy. His journey began with a diploma in Biotechnology from the University of Debrecen in Hungary.


With over 20 years of experience, Zsolt has been instrumental in both early and late-stage drug development. His expertise lies in formulating tablet and capsule drug products for Phase I/II/III and bio-equivalence studies. He possesses a robust understanding of solubility enhancing technologies. As an expert in process development, he navigates the complexities of scale-up and technology transfer.

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Early Formulation

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