Cyprotex ADME-Tox Solutions

Cyprotex serves a number of different industries including the pharmaceutical and biotech, personal care and cosmetics, household products, and the chemical and agrochemical industries. We offer a comprehensive range of different services in the following areas:

Cyprotex eStore

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Cyprotex Unique Technologies

We offer a number of unique technologies either developed in-house or through our collaborators/partners.

eCiphr®Cardio

Synchronously beating iPS cell derived cardiomyocytes are monitored by high throughput microelectrode array (MEA) to measure whole cell electrophysiology and an ECG-like response. This technology provides a unique in vitro system for preclinical drug discovery, cardiotoxicity assessment and disease modelling.

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eCiphr®Neuro

Primary cortical neurons are monitored by high throughput microelectrode array (MEA). The cells recapitulate many features of neurons in vivo, and enable assessment of spiking rate, burst characteristics and synchrony. This technology provides a unique in vitro system for preclinical drug discovery, neurotoxicity assessment and disease modelling.

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CellCiphr® Premier

An extensive panel of toxicological endpoints are assessed in multiple cell types and at multiple time points using high content screening (HCS). By combining these endpoints with exposure levels (measured Cmax or predicted Cmax using Cloe® PK), the system delivers a sensitive and specific prediction of DILI (drug-induced liver injury).

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