3D Microtissue & Multilayer Models
Cyprotex, a wholly owned subsidiary of Evotec, has extensive experience in developing screening techniques using 3D microtissue, spheroid and multi-layer cellular models.
3D cellular models have many advantages:
- 3D cellular models are amenable to long term repeat dose studies which are not possible using 2D systems.
- 3D cellular models closely mimic native tissues and have the benefit of cell-to-cell interactions and displaying their in vivo physiology.
- Most 3D models are amenable to high content imaging as well as biochemical endpoints.
3D Microtissue, Spheroid & Multi-layer Cell Model Services
We can offer:
- Scaffold-free multicellular organotypic 3D microtissue or single cell spheroids models. High content screening services with confocal imaging (available for Ultra-low adhesion plate model).
- Cytotoxicity screening service (e.g. cellular ATP content).
- 3D Hepatotoxicity assessment using high content imaging (HCI) and plate reader endpoints.
- Structural cardiotoxicity and hypertrophy model using 3D spheroids.
- Structural cardiotoxicity model using 3D cardiac microtissues.
- 3D brain microtissue model with high content imaging (HCI) endpoints.
- Mattek’s EpiIntestinal™ model. Contact us to find out more.
Other commercially available 3D models can be implemented into Cyprotex’s workflow, contact us with your requirements.
Cyprotex enables and enhances the prediction of human exposure, clinical efficacy and toxicological outcome of a drug or chemical. By combining quality data from robust in vitro methods with contemporary in silico technology, we add value, context and relevance to the ADME-Tox data supplied to our partners in the pharmaceutical or chemical industries.
