Crystallographic Fragment Screening

Increased throughput achieved by automation around crystal handling and diffraction data analysis has rendered Crystallographic Fragment Screening a much sought-after primary fragment screening technology. In comparison to conventional high-throughput screening methods, it provides immediate spatial information and thus instructs on relevance of the binding site and routes for rational downstream fragment elaboration.

• Establishing high-resolution soakable crystal systems
• Solvent tolerance testing to maximize fragment concentrations and minimize attrition
• Access to Evotec’s proprietary library of 500 highly concentrated X-ray fragments and multiple libraries from Diamond Light Source
• High-throughput crystal fragment soaking
• Parallelized downstream data analysis