BioSAXS
Evotec provides expertise in retrieving structural information on proteins and RNAs in solution via small angle X-ray scattering (SAXS). This technique delivers low resolution information on the overall shape, size and structure of proteins, RNAs and their complexes.
- Requires neither crystals nor special sample labelling
- Not limited by molecular mass or flexibility of the studied molecule
Small Angle X-Ray Scattering (BIOSAXS)
Services offered by Evotec include:
- Probing conformational changes upon ligand binding or environmental factors (temperature and pH)
- Quality control of protein/RNA solutions (oligomeric state, aggregation)
- Investigation of structural flexibility, probing of complex stability or its formation
- Time-resolved studies (oligomeric state, complex formation, aggregation)
- Validation of existing protein/RNA crystal structures in solution
- Integrative structural modelling of RNA structures by employing SAXS and SHAPE-MaP data together with computational methods
Evotec has the right technologies & disease understanding to meet our partners' evolving needs: a comprehensive disease knowledge at the molecular level, cutting-edge technologies & platforms to translate this expertise into effective precision medicines.
