Mitochondrial Toxicity
Mitochondrial Oxidative Stress Assay
Introduction
- Mitochondria consume the majority of cellular oxygen and regulate redox-signalling1.
- Toxic drugs can induce mitochondrial reactive oxygen species (mROS) causing mitochondrial/cellular damage which has been linked to the pathology of many diseases2.
- The Cyprotex mitochondrial oxidative stress assay detects selective mROS production caused by the toxicity of novel compounds.
Protocol
Mitochondrial Oxidative Stress Assay Protocol
Data
Data from Cyprotex's Mitochondrial Oxidative Stress Assay
References
1) Zorov DB et al., (2014) Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release. Physiol Rev 94(3); 909-950
2) Ježek P et al., (2020) Redox Signaling from Mitochondria: Signal Propagation and its Targets. Biomolecules 10(1); 93
Downloads
- Cyprotex Mechanisms of Drug Induced Toxicity Guide >
- Cyprotex Mitochondrial Oxidative Stress Assay Factsheet >
Cyprotex enables and enhances the prediction of human exposure, clinical efficacy and toxicological outcome of a drug or chemical. By combining quality data from robust in vitro methods with contemporary in silico technology, we add value, context and relevance to the ADME-Tox data supplied to our partners in the pharmaceutical or chemical industries.
